TRP Channels and Thermosensation
نویسندگان
چکیده
منابع مشابه
TRP channels and thermosensation.
Recent years have seen great advances in the molecular description of sensory neurobiology. Of the five popularly characterized senses (sight, hearing, taste, smell and touch), touch is perhaps the most varied and least understood. Within this modality is the ability to sense mechanical forces, chemical stimuli, and temperature, and the molecules that mediate this ability have been a long-stand...
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In humans, the TRP superfamily of cation channels includes 27 related molecules that respond to a remarkable variety of chemical and physical stimuli. While physiological roles for many TRP channels remain unknown, over the past years several have been shown to function as molecular sensors in organisms ranging from yeast to humans. In particular, TRP channels are now known to constitute import...
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Phosphatidylinositol 4,5-bisphosphate (PIP2) plays a central role in the activation of several transient receptor potential (TRP) channels. The role of PIP2 on temperature gating of thermoTRP channels has not been explored in detail, and the process of temperature activation is largely unexplained. In this work, we have exchanged different segments of the C-terminal region between cold-sensitiv...
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Nociception is the process whereby primary afferent nerve fibers of the somatosensory system detect noxious stimuli. Pungent irritants from pepper, mint, and mustard plants have served as powerful pharmacological tools for identifying molecules and mechanisms underlying this initial step of pain sensation. These natural products have revealed three members of the transient receptor potential (T...
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Itch (pruritus) is one of the most often seen sensory phenomena in clinical practice. Recent neurophysiological findings proposed the existence of a novel pruriceptive system which includes a multitude of pruritogenic (itch-inducing) peripheral mediators, itch-selective pruriceptors, sensory afferent networks, spinal cord neurons, and certain central nervous system regions. In this review, we f...
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ژورنال
عنوان ژورنال: Chemical Senses
سال: 2005
ISSN: 0379-864X,1464-3553
DOI: 10.1093/chemse/bjh180